In 2016, schools and communities around the world, however none more prevalent than the state of Ohio, are addressing this epidemic with a proven curriculum. This strategy, known as the PAX Good Behavior Game, is a universal preventive intervention recommended by the Institute of Medicine, recognized in the National Registry of Evidence-based Programs and Practices by the Substance Abuse and Mental Health Services Administration, and also shown by the Washington State Institute for Public Policy to have a return on investment of 54:1 – higher than any other social program. This classroom-based intervention is carried out by teachers trained in the program and is packed with research-based strategies convening scientific breakthroughs in neuroscience, behavior analysis, developmental psychology, and even age-old cultural wisdom. The origin of the strategy lies in University of Kansas applied behavior analysis and was later refined by Johns Hopkins University where multiple cohort longitudinal studies remain ongoing and boast gaudy outcomes such as 60 more minutes of instructional time in the classroom, 70% reduction in problematic classroom behavior, 20% drop in students identified for special education services, and 60% reduction in major behavioral offenses. These drastic changes to the classroom environment dramatically improve teachers’ ability to teach and students’ ability to learn, grow, and develop. However, the truly eye-popping outcomes from the PAX Good Behavior Game come when the children exposed to the lessons in empathy, self-regulation, and behavior for even one year in the classroom reach adulthood. At age 21, adults who were exposed to the strategy as schoolchildren see 35% less alcohol abuse, 68% less smoking addiction, 50% less illicit drug dependence, as well as drastic decreases in dropout rates, violent crime, social service use, suicide ideation, and risky sexual behavior. This project proposes a national "scale-up" of this proven intervention in order to improve the health, safety, and prosperity of our nation and world using science to once again save society from destruction as we have in the past. This project proposes making these evidence-based practices accessible to every school and community - not just the well-funded, well-connected but all communities.