HIP–CD8+T: Human Immunoresilience Project Against HIV

I am developing a method of advancing the cure for HIV because HIV does not yet have a cure, and around 1.1 million people live with HIV.

Photo of Praneeth Chitirala
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Written by

Are you employed by T-Mobile or related to an employee of T-Mobile?

  • No

Eligibility: Date of Birth

January 31, 2005

Help us stay in touch!

(203)-892-2634 Connecticut: Milford (06461)

Date You Started Your Project Started

This project was started on 09 / 17 / 2019.

Project Stage: Select the description below that best applies to your approach.

  • Idea (hoping to get started in the future)

1. The Problem: What problem are you helping to solve?

The problem I am attempting to solve is the prevention or hindrance of HIV sepsis to protect the human race from contracting AIDS and allowing the people infected with HIV to maintain a strong and healthy immune system. Although many scientists are contributing to the development of the immunity of HIV, the cure is currently not discovered (the cure is theorized but not executed yet). There are about 37.9 million people with HIV in 2019.

2. Your Solution: How are you planning to solve this problem? Share your specific approach.

To prevent HIV sepsis and to strengthen the immune system of most people, the solution is the artificial replication of both CD4+ and CD8+ T cells in a lab and injecting an immense amount of these replicated CD4+ and CD8+ T cells into the patient’s bloodstream to protect the body from imminent HIV infections. HIV destroys the CD4+ T cells and inhibits the stimulation of other immune cells including macrophages, B lymphocytes, and CD8+ T cells, ultimately weakening the immune system and disabling any HIV-specific adaptive immune responses. CD4+ T cells contain major histocompatibility complex (MHC) molecules, which can recognize invading pathogens. The MHC proteins bind to several different peptides, and if it binds to a foreign peptide from the pathogen, then it stimulates the other immune cells to attack the pathogen. More CD4+ T cells allow the waning of the immune system to alleviate and the production of more MHC molecules to detect invading pathogens easier and faster. With more CD8+ T cells, HIV and HIV-infected cells can be killed faster and efficiently. To produce more of these cells, prophase can be sped up by increasing the amount of condensin and y-tubulin in the cells.

3. Personal Journey: What’s the story behind why you decided to start this project?

I decided to start this project because I want to make the world a safer environment for the current and subsequent generations to experience, and I also want a great improvement in the technological advancements in the future. Another reason why I wanted to start this project is because of the number of deaths HIV that causes today. I am captivated by the interactions between harmful pathogens and the human body. Since I have participated in the Connecticut Invention Convention (where I have received the “McCormick, Paulding, and Huber Patent Award”) and the National Invention Convention, I decided that I want to participate in another technology event that can one day change the lives of many people.

5. Example: Please walk us through a specific example of what happens when a person or group gets involved with your project.

When a person or group gets involved with my project, the project will be hypothesized and tested by pharmaceutical or clinical lab scientists for any flaws that occur within the system of the idea. After this, the project will then be repeatedly tested and form new hypotheses about the topic of the project, allowing for more ideas to form (any idea, significant or not, is worthy of sparking other imaginative and innovative ideas) and progressing to a developmental state. People infected with HIV can get healed by giving a blood group appropriate injection of the replicated CD4+ and CD8+ T lymphocytes to strengthen their immune system for the HIV sepsis. With enough support and time, the patients will be healthier and will be able to rid their body of the HIV sepsis.

6. The X Factor: What is different about your project compared to other programs or solutions already out there?

My project is different compared to other solutions currently existing because scientists are attempting to affect HIV directly, whereas my project utilizes the properties of the numerous white blood cells and other immune cells to create an alarm system to better prepare for an infection. Some methods scientists are using to solve this dilemma include the thwarting of HIV approaching its mature state, the virtual screening of pioneering HIV inhibitors to understand how they react with the virus, and an HIV surface protein that binds to the cell membrane and the RNA to change its shape.

7. Impact: How has your project made a difference so far?

My project currently hasn’t made any difference by this time because my project is just a mere idea and it still requires some time to have its plan officially be executed. With enough positive recognition (people approve of my idea) and support in successfully accomplishing the project, my idea can start to perform at a better standard. I can communicate with other scientists or professors to acquire feedback to adjust my idea and approval for the development of the project.

8. What’s Next: What are your ideas for taking your project to the next level?

My ideas for taking my project to the next level are to arrange a meeting with professors or scientists to further develop my project and make any adjustments necessary to improve the operation of my idea. Then, the professors or scientists I have met with can help in the process of communicating my project with pharmaceutical companies and clinical laboratories to develop and manufacture my project into a functional plan. I can also just directly meet up with the companies to ensure that my idea is sufficient to be performed.

9. Which of the following types of expertise would be most useful for you?

  • Project Plan & Strategy

Help Us Support Diversity! Part 1 [optional] Which of the following categories do you identify with?

  • Asian (for example: Chinese, Filipino, Indian, Vietnamese, Korean, Japanese, Pakistani) (9)

How did you hear about this challenge?

  • Other

Evaluation results

4 evaluations so far

1. Overall evaluation

5 - This idea rocked my world. It’s awesome! - 25%

4 - This idea seems really exciting. With a little more polishing, it’d be among my favorites. - 0%

3 - This has some good elements and some areas for development - 75%

2 - This doesn’t inspire me so much - 0%

1 - It didn’t make my heart beat faster. - 0%

2. Changemaker Quality

5 - Absolutely, 100%! - 25%

4 - I feel really good about this - very promising - 0%

3 - This has some good elements and some areas for development - 75%

2 - This doesn’t inspire me so much - 0%

1 - This entry is weak here - 0%

3. Creativity

5 - Absolutely, 100%! - 25%

4 - I feel really good about this - very promising - 50%

3 - This has some good elements and some areas for development - 25%

2 - This doesn’t inspire me so much - 0%

1 - This entry is weak here - 0%

No Answer - 0%

4. Commitment

5 - Absolutely, 100%! - 100%

4 - I feel really good about this - very promising - 100%

3 - This has some good elements and some areas for development - 100%

2 - This doesn’t inspire me so much - 0%

1 - This entry is weak here - 100%

No Answer - 0%

5. Connection

5 - Absolutely, 100%! - 25%

4 - I feel really good about this - very promising - 25%

3 - This has some good elements and some areas for development - 50%

2 - This doesn’t inspire me so much - 0%

1 - This entry is weak here - 0%

No Answer or No Connection - 0%

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